Our results suggest that MMDP has the therapeutic potential to ameliorate TNBS-induced colitis symptoms revealed by histological change and inhibit IL-17 production.ĭendrophthoe pentandra is an Indonesian mistletoe species that belongs to the family Loranthaceae. The extract lowered the levels of Th17-associated cytokines but increased the production of Treg-associated cytokines in mesenteric lymph node cells. These effects were associated with a remarkable amelioration of the disruption of the colonic architecture, significant reduction of the colonic MPO ( p < 0.05). The extract significantly attenuated the loss of body weight ( p < 0.05). Administration of the extract significantly decreased the severity of TNBS-induced colitis in a dose-dependent manner. MMDP extract potently suppressed colon shortening and MPO in mice with TNBS-induced colitis. T-cells sub-population in mesenteric lymph nodes were analyzed by flow cytometer. On day 8 of the experiment, the colon tissues were removed for histological examination, cytokine and myeloperoxidase (MPO) measurement. The mice were randomly divided into five groups comprising group1 receiving vehicle (the negative control), group 2–5 receiving TNBS, group 3–5 orally receiving either MMDP extract 150, 300 and 600 mg/kgBW for 7 days after TNBS administration. MethodsĬolitis was induced in Balb/c mice by rectal administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS).

The aim of this study was to investigate whether MMDP extract could increase Foxp3 regulatory T cells and inhibits development of Th17 cells.

Mango mistletoes Dendrophthoe pentandra (MMDP) extract has attracted interest due to its pharmacological properties, including gastro protective effects.

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